In theory, as long as you do not compress the spring beyond it's yield limit it should not degrade.
As nearly as I can tell, some double-column magazine designs actually compress the springs beyond their design limit. Here's one interesting example that points in that direction.
I read a torture test in a magazine in which a large number of rounds were fired through a brand-new pistol using double-column magazines. There were two new magazines being used for the test. About a third of the way through the test the magazines began to fail to lock the slide back on empty and perhaps showed some issues feeding the last round or so.
The springs were replaced and the shooting continued, but with one change. The magazines were consistently underloaded by 2 rounds for the remainder of the test. They were still operating perfectly at the end of the test. Underloading by two rounds increased their functional life by AT LEAST a factor of two. In other words, in spite of being CYCLED twice as much they still operated fine--clearly reducing the depth of compression increased their life considerably. The only conclusion I can see from that sort of result is that the spring is being compressed past its design limits when the magazine is fully loaded.
Now, I do NOT believe that ALL double-column magazines share this failing, but some clearly do.
I test them often (as I practice often). If I ever notice a problem I'll just buy another magazine or magazine spring.
Given frequent testing and the low price of magazine springs, this is a very reasonable approach.
The only thing that concerns me is that a lot of people have swallowed the lie that springs absolutely will not weaken from being left compressed. In the ideal case, that may be true, but in practice, some magazine designs apparently put enough stress on the springs that they will weaken considerably from being left fully loaded.
If you plan to leave a double-column magazine loaded for a LONG time without testing it, underloading by a round or two is prudent. A better approach is to frequently test your equipment as Flechette does. This will help you to learn about the limitations of your equipment and enable you to detect issues and deal with them before they become problematic.