God, what a bunch of girls.....357 is okay, but hot .45 Colt is mo bedda, at least until I can get a .454 Casull.
Out of a K frame, 14.5 grains 2400 behind a Lee gas checked 158SWC is a pleasure! I really had fun with the little SP101 with 180 grain XTPs at 1302 fps with 13.8 grains AA#9. That one will wake you up.
I shoot the lighter 158 grain load for 99 percent of my shooting same reason as 1911Tuner does, it's easier on the guns. Actually, it puts down deer quite well, too, ain't THAT mild, just a tick off the fire breathing hot of some of my other loads. It puts up 1470 fps or so out of my 6.5" Blackhawk and is quite accurate. It puts up something around 1850-1900 fps out of my Rossi 20" M92 carbine, deadly on deer to 100 yards. I like the 180 load for hunting, but it's kinda warm and I can't afford to be bustin' caps on store bought bullets anyway. That 158 grainer I cast from range scrap for the price of a gas check. Absolutely no bore leading even out of the rifle.
The .45 ACP has less recoil, less muzzle blast, less muzzle flash and less muzzle rise. It can be used in weapons that fire and reload faster, and is near the top of the rating charts for stopping power.
But, it ain't no .357.
If all you do with a handgun is self defense or small game hunting, nothing wrong with lesser calibers. I carry a .38 and a 9mm a lot, more compact pocketable guns. I have a .45, but it's frankly easier to carry the more powerful .357 magnum and if I carry IWB, that's usually what I'm totin'. It's lighter, more compact, easier to tote IWB, and I shoot it well. I have always liked magnum revolvers. Nothin' like horsepower to get the job done. Needs a 3" barrel or better, though. That's one bane of the .357, the snubbies are neutered. I sold my SP101, will get a 3" if I get another. I have a Taurus 3" M66 and it shoots harder and with the extra sight radius, I can shoot it better. It's not a whole lot harder to conceal than the SP101 was.