I have a Pedersoli .45 flintlock, with 1/66 rifling, (kit) that I took a 150# N/E Wisconsin forkhorn whitetail with about 10-15 years ago. The shot was right at 50 yards nearly broadside, the round ball took the right lung, coming off a rib bone, pierced the heart, and was recovered just inside the hide on the far left side. Incidentally it was a nice clean kill. That is the only deer I took with that rifle, and although I had it sighted in out to 75 yards, that is about the furthest distance I would expect a .45 round ball to perform, flintlock, or percussion. I do prefer the .50 caliber using the mini ball to be far superior for humane kills on deer sized game animals. BTW I used a patched ball as prescribed by Harold V. Schoultz, using the 8-1 formula.