Like Jim, I don't push it any longer, i.e., use the proper weight bullet with the proper twist rate barrel. However, in my experimenting days (about 35 to 40 years ago) I did.
Digging through my old files I found that I used both a 60 and 63 grain bullet in a Remington 788 with a 1:14 twist rate. Both bullets were stable and accurate. But I never loaded to the max with either one so the velocities usually associated with a 22-250 were never reached.
I used a Sierra 60 gr. HP and a Sierra 63 gr. Semi-point and 33.0 gr. of DuPont IMR 4895. I got the load data from Hodgdon's Manual #20. The load for the 60 gr. bullet wasn't listed, but I noted that the same 33.0 gr. load of 4895 was safe with the slightly lighter bullet.
A little later (about 15 years ago), I also tried a Hornady 68 gr. BTHP even though they didn't recommend it in a slow twist barrel. Know what? They're right. I was using 31.0 gr. of 4064, again not pushing the max, and the results in the target were perfect little keyholes.
In fact, I must have loaded them quite consistently, because the keyholes were all oriented in precisely the same direction so the bullets must have been tumbling with the same rotational velocity.