I haven't shot any game yet, but am getting excellent results at the range with 130 gr TTSX's @ 3050 fps from my 308. I've talked to enough hunters online that have used them successfully to be confident of them working,
if used properly. Lots of guys try to use the same bullet weight they would use with conventional bullets. This is my deer/black bear load for next FAll.
Forgive me if you already know this, but I've done a bit of research and this is the advice I have gotten about Barnes bullets.
The original X bullets do not expand as reliably in 30 cal and under. Shoot the TTSX unless you are shooting a larger caliber.
The TTSX bullets need speed at impact to work. At least 2000 fps when you hit game, or it may not expand. To do this drop down at least 1, maybe 2 bullet weights, you will get best results if you can have them leave the muzzle at around 3000 fps or more.
Don't worry about the light bullets penetrating. Even at ultra high speeds they maintain 98%-100% of their weight. A conventional 165 gr bullet @ 2700 fps would only weigh around 100-130 gr after impact. The 130 TTSX will give equal or better penetration @ close to 3100 fps.
The downside:
Because they need speed at impact, and light bullets slow faster at long range than heavy bullets, they are not a good choice for longer range shooting. My 308/130 gr load is still over 2000 fps out to 400 yards though.