I have carried Smith autos for many decades now. The only time that I engage the safety is when the gun is stored outside a properly fitting holster.
For example, you need to go in the courthouse, take the gun out of your holster, engage the safety and put it under the seat of your auto, or you stuff it in your waistband for a quick trip somewhere. I like the having the ability to use the safety where I deem necessary. However, I do not use it for holstered carry.
However, If you were required to use it for holstered carry, you should be able to master the technique in about 5 evolutions.