The only safety I never had a problem with was the thumb safety on a 1911. As you draw, your thumb naturally encounters the safety and as the thumb comes down into the gripping position the safety gets pushed down and you're ready to go boom. It's a natural movement, whereas with a shotgun or a rifle you must remember not only where it is and which way you move it, but also whether it's on or off. And at night the little red dot is useless.
Pistols with no safety, such as the Nano and the Glock need a heavier trigger pull to minimize the chance of an accidental discharge. Probably why so many law enforcement agencies use Glocks, including the Arizona Ranger company I'm in.
If Rail Driver finds the Nano trigger "mushy" that's fine. Mine does not have a mushy trigger. Long pull, sure, it's a DAO, but so do the Keltec 3AT, Ruger LCP, and the Kahr 9mm, all long pull DAO's. I like 4lb. triggers too, and they can be found on SA revolvers and SA/DA guns like Smith&Wesson and 1911's. I'm not sure that anyone makes a DAO pistol with a 4lb. trigger, but what do I know?
Bill: Wish I'd have known about Nate2tactical.com, I could have saved a few bucks. Does it appear similar to the Beretta IWB?