I agree with bulldozer and theb - those +P rated 158gr LHPSWC .38's were made for short barrels. I chrono-ed the R38S12 Remingtons I shoot at 834fps from my 2" 10 and 904fps from my 3" 65. They, from short barrels, have a proven record as one shot stoppers in close encounters. Additionally, anything sub-sonic, like the aforementioned LHP's, will do less damage to your hearing, not to mention to your neighbors after exiting your interior walls(collateral damage...), allowing more aural input during a stressful time. While the loud boom of a subsonic .45 will definitely desensitize your hearing at least temporarily, the supersonic 'crack' of a 9mm or .357M will cause more longterm damage.
My side of the bed has a 296 with 200gr Gold Dot .44 Specials (~804fps) while my wife's has the 3" 65 wiith the 158gr LHP's. A similarly loaded 10 resides close by as well. Of course, for wayward pachyderms, my .454 SRH is in another room with a myriad of loads just a few feet away...
Oddly, the first thing I grab at night when I hear a noise is still a flashlight... and my wife still has her baseball bat...
Stainz