What I've found, after building and rebuilding hundreds of AR's in the last couple decades, if you can't get 27.3grn Varget under a 50grn V-max to shoot well in a 1:9" to 1:6.5", something is wrong with your rifle.
The 50 Vmax is a violently expanding bullet design, and in the absence of barriers and armour, will produce very quick kills on game, and I'd expect the same performance on human recipients.
The best news about the 50 v-max, there are a bunch of factory ammo options which use this bullet. The Remington 50grn Accu-tip is the same 50grn V-max, just with a green tip, then other loaders like HSM load the 50 vmax as well. For the reloader, they're super cheap.