Faster is not better!!! Necessarily.
Let's not forget that higher/highest velocity in and of itself is NOT the most important objective of defense terminal ballistics. What's most important is matching the velocity of the bullet to the design parameters of the bullet.
Let's take the 230 gr. Gold Dot bullet for example. This bullet was designed to expand fully and penetrate an average human target a desired 12-14" or so with a velocity window of, perhaps, 800-900 fps. If you push that bullet to 1100 or 1200 fps, you may well cause overexpansion and underpenetration... depending, of course, on the physical nature of your target.
If you drop that velocity down to 700 fps, then expansion may not occur much, if at all, and penetration might also be insufficient as well. Ideally, we want to move our bullets at the speed they were designed to perform best at, given the likely make-up of the target.
The 200gr. .45 cal. Gold Dot pushed to 1100 fps will most likely prematurely overexpand (disintegrate?) and fail miserably in penetrating an elk's body, while it may perform effectively on a slightly-built 140 lb. human, wearing just a t-shirt. Same loading facing a 275 lb. heavily built, heavily clothed human adversary in winter time (lots of clothes) may result in total failure of the bullet to achieve it's desired objective. Disintegration with very shallow penetration. Slow the bullet down to 850-900 fps and it is more likely to hold together a bit better and penetrate more deeply.
In answer to the question... the best velocity for a given round is NOT "as fast as you can push it". It is that which the bullet was designed to perform well at, given the intended target.
Most .45 acp 230 gr. JHP bullets are designed to perform well against human adversaries at velocities of about 825-900 fps. You are best off adjusting your powder levels/barrel lengths to try to be within that velocity envelope for that particular bullet.
In winter time I prefer heavier bullets for caliber because they tend to penetrate best. I assume my adversary may well be very heavily clothed, very heavily built, and possibly very heavily under the influence of some substance. Penetration is king. You are likely to have to penetrate an arm orr two before even beginning to try to penetrate body clothing, layers of fat and or muscle, and then finally getting to vitals. Go for penetration and get expansion if you can do so without sacrificing penetration.
In the heat of summer, I anticipate that my penetration needs may be somewhat less and I might shift toward a bullet which would expand a little more readily and not have to stand up to lots of layers of clothing. Of course, there are many, many variables which must be considered in making your caliber, platform, and load choice.