Countless arguments, tests, actual police shootings etc, have led me to believe that the .357 with a 125gr. DOES impart hydrostatic shock to a man-type target (boy, is that polictically correct, or what!), with the 125gr. HP .357 dominating the charts of one shot stops in acutal police shootings. The .45 gets better results than many other standard police rounds, even the new ones. However, portability, gun handling, familiarization etc, might cause anyone of us to choose one over the other. If you like autos, you should be well armed with a .45. If you like revolvers, and are not intimidated by the blast or sharp recoil of the .357 full loads, then the .357 may be for you. A revolver guy can move up to the .41 or .44 Mag, too. An auto guy might like the 10mm, which just may EXCEED the .357 in most every way. Bullet placement will easily put one over the other, MAYBE every time.