This is one of those "It depends" question/answer things. I have a Blackhawk in 45 Colt, and I've shot it a lot.
Many of the loads you see in the manuals for "Ruger only" are just barely above the high end of standard loads, and my brass lasts about 10 times through the sizer if I keep the loads in that range.
If you will keep your loads to mid range type plinking rounds, say a 200 LSWC at around 800 FPS, the brass lasts a long time. Maybe 20 loads if you are careful not to over crimp. The case mouth seems to go first.
If you're going to really hot rod it, like 260-300 gr jacketed bullets in the 1150 FPS range, case life drops to 4-5 reloads and then the neck will split badly. You have to put a hard crimp in these loads, and the neck is kind of thin on 45 Colt brass. It takes it's toll.
You'll probably find yourself shooting more of the mid range to medium-hot loads than the barn burners, simply because the gun will beat you up a bit with the fast 300 grain loads. It's not a plinking round, for sure. Besides, the old Colt in it's original loading is no slouch, and very comfortable in the Blackhawk frame.