Your bullet choice is good and so is your powder choice. I'd recommend magnum primers from the get-go for either powder. I find that they are a little hard to light off and with magnum primers, they seem to burn more efficiently. In other words, I find them more consistantly accurate with magnums.
Good luck with your load and hunting with it. I took a hog with the 180 XTP from a Ruger GP 100. Showed good penetration and also good expansion. Hog was DRT-just like you want.