JRH6856
Member
When the question is whether cheap ammo is as good to carry as quality ammo, then yes its pretty meaningless.
The OPs question did not ask about "cheap" ammo. He asked about "budget defense" ammo. In order to even be considered as defense ammo, it must be demonstrated to be functional and reliable so questions of charge consistency and unfired primers are not at issue.
With an acceptable level of manufacturing quality being necessary for consideration, the only relevant differences in defense ammo is pressure level, bullet design and performance. And shot placement is certainly withing the context of bullet performance.