If you have a mill & lathe, I highly recommend dabbling in monocore designs, especially for rimfire & pistol. I'm an RP on an 07/02, and my title in the shop is gunsmith/machinist/R&D guy, so I've been able to play around with some different designs. One that is relatively easy to mimic on manual equipment and extremely effective is the Gemtec .22 design:
Now, drilling a straight hole 6"+ long absolutely requires a decent lathe, and obviously the baffles are mill work, but for low pressure rimfire and pistol rounds, you can use aluminum, so it goes pretty fast. It's quite a bit quicker than making individual baffles and end caps if you're tooled up to do it.
I'm not going to show you our design right now, as it differs a bit from the Gemtec and may be patentable, but the basic concept is similar, and it's every bit as quiet as the best production cans. It also weighs just 2.8 ounces.
If you're going to do handgun suppressors, you have to incorporate a booster, but that's no more difficult with monocore than conventional baffle arrangements.
Monocore for centerfire rifle could be done similarly, but you're gonna have to use steel, stainless, titanium or inconel if you want it to hold up.