Colts= High, Rem= Low (Mostly!)
Folks, I've been popping rounds with these weapons for a touch over 45 years. Those few originals I've owned/shot did go a might high with standard loads. The reproductions did the same. Colts almost always hit high. Short front sight....makes sense. Remingtons almost always hit low. Tall front sight...again, makes sense.
I have a 2nd Mod. Dragoon made in 1965 that hits 2" high at 25 and dead on at 50. Great hunting range and the weapon has taken dozens of deer and hogs. However, I just recently got my hands on a slightly used Pietta Remington 1858 .44. This weapon is dead on at 12 yards, but almost 4" low at 25. Simple solution, find a load that prints a tight group, and then file the front sight down (GENTLY!!!) till I get about 2" high at 25. (I'm thinking hunting range again as usual)
As a former gunsmith for about 30 years I've made some adjustments to some pistols at the custimers request to shoot POA involving shallow dovetail rear sights and blade sight up front on the Colt style weapons. The Remington style revolvers were far easier to adjust. It is my opinion that the design was first intended as a close quarter weapon and was never intended as a "target" pistol.
Studies of historical events where these weapons were deployed in combat clearly show that most lethal shots were made at a few feet and not at 25 yards taking your time to aim. I have many letters that my family had saved from two ancestors that were in the Civil War. Reading some of them told of intense battles that they were involved in. One was a cavalryman, the other was in the infantry. The cav member spoke of shooting so close that some shots caused uniforms to smoulder from powder burns. Judging from the descriptions of the combat these two were involved in, the pistol shooting was just point in the general direction of center mass and fire.
So, I'll shut up now and if your Colt style shoot high, it's kinda the nature of the beast to do so
Wade