The .44/40 has had a checkered reputation lo, these many years.
Elmer Keith in, "Sixguns", the BIBLE for basic handgunning, noted that the case blows out full length in Colt chambers, which removes the bottle-neck effect, shortening reloading life. He had better luck loading this round with black powder. Said that it and the .38/40 were unreliable with smokeless ammo.
On the other hand, Mike Venturino, the current gun writer most experienced with arms of this vintage, says that he likes the .44 and has no problems with it.
Might vary with the gun.
I'm with those frontiersmen who stuck with the .45 Colt.
Lone Star