I have a CrossBreed for every one of my carry pistols. They're so comfortable, you may literally forget that you're carrying. I use mine carrying 14 hour days, hunting, hiking, you name it. I've tried a Comp-Tac and prefer the CrossBreed. I've also tried a couple of the injection-molded IWB holsters. They're nowhere near as comfortable.
I have a couple horsehide and a couple cowhide CrossBreeds. The horsehide is slightly thicker than the cowhide. If you live in a humid climate, I would recommend the horsehide over the cowhide. Otherwise, there's little appreciable difference between the two.
I do prefer the combat cut, but that's something that anyone with even the slightest DIY abilities and a heavy-duty pair of kitchen shears can do themselves.