Axeman,
I feel your pain, my friend!
Being left-handed, I developed a system that works well for me. I use a two handed hold on the gun. When the revolver is empty, I slide my right hand around to the grip, while depressing or pushing the cylinder latch. At the same time, my left hand slides under the frame, and my middle fingers push out the cylinder. I now have the gun "opened' and in my left hand, with my middle fingers through the frame and controlling the cylinder. Flip the wrist, and point the barrel up, push the ejector rod with the left thumb, then flip the wrist again pointing the barrel down.
While empties are ejecting, my right hand goes to the belt and grabs a speedloader. The cartridges are inserted, the left hand closes the cylinder, the right hand comes up and supports the gun, allowing the left hand to slide back into firing position.
It sounds complicated, but once you've done it a few time, it's lightning fast.