Depends on how many walls you're trying to shoot through.
If you have to shoot through multiple walls to get your bad guy, then used the .40 or .45 pistola.
If you have clear view of the bad guy and would rather keep the number of walls punched down to a minimum, then you want a round that fragments faster and stops earlier, that being the .223 ammo.
I cannot let this comment pass:
Depends on how many walls you're trying to shoot through.
If you have to shoot through multiple walls to get your bad guy, then use the .40 or .45 pistola.
If you have clear view of the bad guy and would rather keep the number of walls punched down to a minimum, then you want a round that fragments faster and stops earlier, that being the .223 ammo.