I'm assuming most modern load manuals allow for the small amount of variations between the different lots of the same powder. So as long as one stays within the limits of published loads there's no real danger mixing different lots of the same powder. Since I only use a few powders and I keep them relatively fresh, I always figured that by mixing the remains of my last jug into the new jug of the same powder, that the result would be a powder closer to what I had been reloading.....thus helping to retain accuracy of loads over a period of time. But then, I too only shoot for fun and for hunting and not for 1000yd competition.