I think the prior answer was correct for older Witness guns, when there were two frame sizes, but doesn't apply to current production guns. With the newest Witnesses, all calibers use the same frame -- or, at least that is my understanding.
I've had both types of the older guns, and the 9 and .40 shared the smaller frame, while the .45 and 10mm used the larger frame.
So, now, you can get different top ends and mags for a single frame: .22, 38 super, 9mm, .40, 10mm, and .45.
I had a .45 and 10mm (two slides, a single frame), but never compared the barrels. (One was a Long Slide, and the other wasn't, so there was no swapping.) The 9mm and .40, and the barrels on the smaller framed guns were the same diameter on the 9mm/.40 guns; you could swap the top ends or just barrels. Even the mags would work interchangeably, but neither would work as smoothly when using ammo from the other caliber.