These discusions are often interesting, nearly always amusing to a point. I'm usually surprised (should I be?) by the number of comments from folks that I believe have not killed things before, or not payed much attention when they did kill things. Not saying that's the case in this thread yet, just saying,....
I for one would prefer to be slightly, or even way "overgunned" than under, given the choice. What may be "enough" in "most" cases, may not be enough in the one time it matters, to me (like say, a 6'4" 345 lb psycho). "Pretty good" doesnt sound as comforting as "outstanding" when I consider the issue.
I choose penetration and tissue damage. Energy may be a byproduct, but not the determining factor to me. I don't believe energy per se kills. How well a particular bullet functions is important. Round nose bullets perform very poorly compared to flat points, semi-wad cutters or working hollowpoints. Go kill some game with the various types and report back if you don't agree. Not wanting to cause conflict, just my observations after shooting game over a number of years with various guns and loads. I certainly don't mind if a particular bullet exits something. If it didn't, it may not go deep enough on a poor shot. I'd as soon a bullet go through anything I want to shoot from any angle, and no matter the size of the critter, and still expand well.