I actually did this last weekend. I am pulling a large lot of steel case factory ammo for a friend, and when I started, for the first 20 rounds I weighed the powder to see what it was. Surprisingly enough, the powder weight was pretty much bang-on for every round - no variance to speak of. This particular lot was 45 Auto and weighed on an RCBS 505..
You didn't specify caliber or manufacturer, so YMMV.