Little piece of trivia: the Glock 21 is actually the only pistol that is a 10mm adapted for .45ACP. All other 10mm handguns on the market are either purpose-built one-caliber guns (like the Bren Ten), or .45 frames adapted to 10mm Auto (like the Delta Elite or the S&W 10xx series.)
The Glock 20 came before the Glock 21, and the G21 is a .45 based on the G20 10mm platform.