Well, it beats up my hands only if I grip it wrong. Shooting SSR (and shooting bunny fart loads in the 625 back when it was SSR), I got used to shooting with both thumbs up high--with the tip of my right (strong hand) thumb riding over the cylinder release and touching the back of the recoil shield; off hand thumb riding the frame beneath the cylnder.
This grip makes for a great DA trigger pull and fast pointing, but when you get the power factor up past 150 or so, the hump at the top of the handle starts biting into the joint of your strong-hand thumb pretty good. If I can't wear a glove, I'll just have to develop another, probably a more orthodox, revolver grip for ESR.
Thanks for the input and answers.