I would definitely verify floor slab and subgrade before going any further. If you do need to replace a portion of the slab, I would consider adding a vapor barrier. IMHO, a conventional, continuous footings and a 4” slab is all you will probably need (unless this thing is going to be really tall). As far as the ceiling, I would cast in place concrete and reinforce it with #4 re-bar 12x12oc and a pretty fine mesh of WWF below that (just in case that F4 through a F150 on it, it would help keep the smaller, fractured pieces from falling on you).
If you cast the ceiling yourself, at the very least, talk to someone in depth about bracing. If it collapses during construction, best case it makes a huge, expensive mess; worst case it kills someone.