When I bought my 1st Colt SAA 44spl, it came with a few hundred rounds of Keith type SWC bullets, 275gr, loaded over 6gr Unique. I did not like them. Less then 700fps MV. They were good for taking the heads off cotton tail rabbits though. I had an opportunity to shoot a mule deer on the last day when we were leaving camp. Real nice buck broadside at 20-25 yards. Unfortuately a rifle was not handy or it would have been the biggest mule deer I ever got. I hit him in the chest behind the front leg. The big bullet knocked him to his knees and before I could get another round off he ran into a mesquite bosque. Never found any blood or him again.
My personal preference in 44spl size sixguns is 180-200gr bullets, 230gr being the heaviest, jacketed or lead, and whatever weight shoots best groups in the particular gun.