But even with unsupported chambers, ka-booms are rare, if proper precautions are taken. 40 S&W seems to be the worst offender these days. The 40 operates at very high pressures and the case heads, at least in Federal brass, tend to be a little on the weak side. Now if you fire this factory 40 through an unsupported barrel, you probably won't have a ka-boom. If you reload, you begin to set yourself up for a ka-boom. As brass is expanded and resized, it work hardens. The area that is unsupported thins and also hardens. This creates a serious weak spot that is likely to rupture.
Another problem usually associated with polygonal rifling is the lead build up if lead bullets are used. This is not a problem unless the shooter allows the lead buildup to become excessive. This has the effect of placing a restriction in the bore and operating pressures skyrocket, leading to a ka-boom.
I think the most common causes of ka-booms are reloaded rounds with too much powder or a round without a powder charge followed by a live round.