At least with an 'Open Top' design, if it blows, you would not loose the Top Strap!
Lol...
I am confident that many people in the late 1880s and into the 1890s, used early Smokeless offerings in their erstwhile Black Powder Cap & Ball and Metallic Cartridge Revolvers, as well as in their Long Arms.
Several Brands of early Smokeless were in fact advertised for just these applications, and, had cautions and Loading data on the Can.
Overall, as far as I have been able to find, these early Smokeless POwders were well received and well thought of, and, likely, there was little misadvanture in their use.
How many people goofed up and bulged or blew their Gun, is anyone's guess! But, probably not a whole lot.
In my opinion, to do it safely and well, now...the amount of knowledge and experience necessary, would also be more than enough to find an alternate solution anyway.
Like that guy in the movie "The Road".
For Pete's sake, if the people-populations had been decimated, and, Cities abandonded, would there not be a lot of Guns and Ammunition to be found by merely looking in likely places?
Yet he was stuck with that albeit nice enough old Model 10 S&W Revolver, he was hard pressed to find any Ammunition.
He was an intelligent resourseful man, and, he could have just done some dedicated looking for regular boxes of .38 Special Ammunition, and, found all he wanted, I am sure.