There are as many answers as there are hunters. MY PERSONAL favorite is a light weight little Remington M7 Stainless in .308 Winchester. It has the power, it has the accuracy, it has a reasonably flat trajectory, it's light and compact and can do it all. It's topped by a 2x10x40 Weaver KV in Millett mounts and rings and sporting Millett "scope topper" iron sights.
If you don't agree with my choice, that's your prerogative and I'm not adamant about it as I know how many good choices in caliber, rifle, and scope there are on the market. The good combinations will work. I would caution to stay in the $150 or up range on optics. Cheap optics can suck. I've owned some that were decent, but there is some junk out there, especially below 100 bucks.
I do love the little M7, very accurate, yet light to carry and short to maneuver in the brush or a stand or box blind. It's even available in some short magnums now, but .308 is all I'll ever need. It's ideal for deer/hog country. I like the 2x10 as it gives plenty of magnification, but low power is necessary in the brush and 2x works great. It's an all around rifle for western mountain canyons to south Texas heavy brush to even southern forests. I have other rifles, but this one is my go to rig.