Although I would only use the .45 for self-defense, I think the .22 cal or the 9mm would both be dangerous depending on where you were hit. Most of the homicides in our city are with the .22 and .25 cal. weapons. Sometimes with only one shot. So either one could be deadly.
There is very little use for the .22 or .25 cartridge, and some experts, like Cooper, feel that there is none at all. It is neither accurate enough to be used in a working gun even one confined to the smallest game -- nor powerful enough to be used for defense. But, these cartridges will kill. If you are aware of the limitations, you use it at little more than arm's length and are cool enough to shoot for the eye sockets, it may give you a 5% chance of stopping an attack from a single assailant. If your unarmed, chances are zero.
Now as to how criminals seem to be able to kill with this cal. I believe it is because they are close to the person they want kill. So I don't want to be hit with either the .22 cal. or the 9mm.
Mrs. Toro
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Matthew 28: 18,19
And Jesus came and spake unto them, saying, all power is given unto me in heaven and in earth. Go ye therefore, and teach all nations, baptizing them in the name of the Father and the Son, and of the Holy Ghost.