Um......probably not really. Not worse, but I can't see any serious advantage.
I used to drool over trick rounds I saw in catalogs, things like a 1/2 slug/00 buck load, or "bolo" rounds, with two .50" balls connected with a 6" piece of piano wire, flechette rounds, etc. I just decided as I learned more that you can use slugs, or good buckshot, but there's not really a good reason to mix them. (Either in the shell OR in the magazine.)