My answer would be since Florida apparently in their hunting regulation
don't define ANY legal firearm for the taking of any game you would typically shoot with a firearm, Contact them direct and ask them.
but Florida's law states this:
FAC 68A 1.004
(45) Muzzleloading gun – A firearm that cannot be loaded from the breech and is fired by wheel lock, flintlock, percussion cap, or centerfire primer.
but based on this, then yes you can.
But based on what you intend to hunt the question would then be
would it be wise, prudent and appropriate.
And is it legal for that game species.
Also some muzzleloaders are not included as legal, such as the CVA Electra.