If you check Dillon's web site, they mention the 550B as capable of handling rifle calibers, due to the manual indexing.
I don't own an auto-indexing press, but I understand these are a little more difficult to deal with as you have to defeat the auto-indexing to interrupt the reloading process and deal with bottleneck brass issues such as trimming, chamfering, and cleaning off excess lube.
Which Dillon reloader is right for you?
What is involved in changing calibers with these two presses, and why is it a PIA?
As I own a 550B, I can answer for that press. -
1. You have to change the toolhead, typically already set up with the dies for a particular caliber and a powder measure and powder funnel. (For pistol calibers, the powder funnel handles case expansion, too.) Two pins secure this to the frame, so it just slides out after removing the pins.
2. You
may have to change the shellplate. One shellplate may fit several calibers (like .45 ACP, .243 Win and .30-06 Sprg all use the same shellplate.) There are sized locator buttons that match the shellplate. Changing the shellplate is probably the most time-consuming, but it isn't hard. You loosen a setscrew on the main ram, unscrew a center bolt and slide the shellplate out, without losing the spring and ball detent. Replace with a different shellplate. Tighten center bolt until shellplate won't turn, then back bolt off a little, tighten setscrew.
3. You
may have to change the primer feed assembly, which consists of the primer slide and primer magazine, if you are changing primer size. The primer slide changes easily, and the primer magazine has a knurled collar that secures it and it also changes easily, sliding out vertically.
IMO, you can fight the press, or you can make the process easier by doing things like running the primer magazine empty before changing sizes, and by using Dillon's toolhead holders to keep shellplates, locator buttons & toolheads organized together on a shelf. The plastic ends of the primer magazines and magazine loading tubes wear out and you need to have spares on hand.