I’ve gotta take exception with what JackOfAllTradesMasterAtNone says above. The number one cartridge I’ve seen in the hands of Alaskans hunting moose, caribou, bear and other game is still the .30-’06. It’s not my cartridge of choice for up there, but if that’s what I had I certainly wouldn’t be “insane” to hunt with it. I think that you can argue that it is under-gunned for some shots from some angles, and I think the only way that a ’06 165gr combo would be suitable is if premium bullets are used, but I think he’s painting with a pretty broad brush to say that the ’06 is insane.
I wonder what he’d think of my uncles and grandfather who used to hunt up there with just their .30-30’s. Thousands of every game animal in the state have fallen to hunters using 170gr flatnose .30-30’s.
Myself, I’ll use my .375, ‘cause I already have one, and that’s a cartridge that won’t cause me any problem from any reasonable distance, for any angle of shot, on any game in North America. But if I were to go up hunting again, and my H&H wasn’t available, I’d feel very comfortable using my old ’06.
Your .300 savage, loaded properly and shot within reasonable distances and at animals presenting good targets, will humanely kill everything on this continent. And, at the same time, I’d recommend that you get an ’06 to go along with it, ‘cause it’s the same, only more so.