I ran out of CCI-250's once and tried using the CCI-200's (standard) instead, but it was for a powder that recomended the 250's (mag) primers. Performance was very noticeably effected. I had what seemed like burning powder blowing back in my face and a large amount of powder debri in the barrel and brass. Over all, I ended up with a very dirty burn. Velocity and accuracy was erratic as well. RL22 was the powder I used for a 7mm RM application.
But going the other way, as in substituting magnum primers for a standard primer application would probably be OK, providing you do a complete new work up though.
GS