I worked up a LR load several years back with the 162gr Hornady BTSP. I looked at tons of info on powders and bullets including the different BC's of them, running predicted velocities through ballistic programs and it came down to the Hornady 162 and the Berger 168gr. My development also included cost which at the time the Hornady's were a LOT cheaper, and much easier to get hold of.
I was working with several powders and also used moly coated bullets in a hand lapped and polished Sendero barrel. The results I got was that RL-19 gave me the best velocities as well as the tightest groups out to 300yds, with this weight bullet.
Not sure what your end use is going to be, but I was working on a hunting load, and using 600yds as a max range. With this in mind, I worked it every possible way and the 162's worked out better all the way around. I got more actual velocity and energy, with less drop/holdover than with the heavier bullets.Now at ranges further on out the heavier bullets do have the advantage, and powders like RL-22, 25, H-1000 will have an added advantage with them.
Good luck with your development, hope this adds some light on it.