When my brother-in-law was a kid, he
was out in a large field with his 22 rifle (just plinking around like kids do) and there was a crow standing about 400 yards out there.
He showed me about where he was and where the crow was standing -- just this side of RR tracks. He said he aimed way over the crow, knowing he would most likely miss. He touched it off, and the crow fell over dead.
He said he was scared to death, but went and got the crow, the bullet went through its head. That wasn't a shot I took, but my B-I-Law's shot.
The best shot I ever took has to be about 70 yards with my Ruger Mark II Target Pistol single-handedly (as my left arm was in a sling from shoulder surgery two days prior -- in 2005) and, resting the barrel on a neighbor's wooden porch banister on a 10 degree below zero morning, put an Ely Target Pistol bullet through the red squirrel's neck with one shot using open sites with a Volquartsen rear site. The neighbor had been having quite the squirrel problem and in about three days (about 40 minutes each morning), I shot 14 of them. They were actually getting behind the plastic corner posts of his vinyl siding and making their way up the corners and out of the vinyl eave soffit! I told him he must get rid of them or his home will be infested with them. I know there was a lot of luck involved in that shot, but I did hit the squirrel, and when it dropped out of the tall tree, I was surprised, when I finally got over to it (in three feet of snow), I couldn't believe the shot was right though its neck with blood all over the snow!
I do have a lot invested in that target pistol (trigger sear, trigger, etc).