Get a Ruger .22 pistol, and you won't think .22LR is unreliable in a handgun any more.
When I took my mom shooting for the first time in her life (had to nag some--I want her to eventually own a gun and be able to defend herself with it), I decided for kicks to rent a Ruger Mark III 22/45 because I had never fired one myself, either, and I wanted a light trigger pull for her to start out with. After the first magazine load the darn thing jammed on us every 3-4 rounds.
We tried a different magazine, and it still kept jamming--mostly stovepipes, but a few rounds annoyingly diving under the feed ramp, too.
We were shooting Mini-Mags, which I've always found to be quite reliable. Granted, it was a rental gun, but if these things need to be kept clean to not jam constantly, then they're not exactly the easiest to maintain, either. Take this for what it's worth--it's also possible that this particular gun needed repair or was simply a rare lemon, for all I know.
So anyway, we traded for a revolver, a Smith & Wesson 617 that I had shot before, and never had a single failure to fire among the nearly 200 rounds after that, which shows that a good batch of quality .22 LR ammo can be reliable. I've certainly used worse ammo in this caliber that failed to fire every so often (though still infrequently).
I don't have any trouble, and I shoot matches with .22 pistols, so I'd notice if I did.
Maybe I just had bad luck, then, but from what I've experienced regarding .22 LR, no gun is going to make cheap, low-quality ammo reliable. Like most everything else, quality control is what ultimately determines reliability, and is often lacking when it comes to the extremes of scale of this case, with low cost, small size, and a massive volume of production.