I've never read in any handloading manual or on any container of powder that it is OK to mix powders, not even of the same exact type. Quite the contrary, don't mix powders even if they are of the same type or lot. Everything stated in the hand loading manuals is developed by individuals who have the equiptment and education to be considered scientists, qualified experts in their relevant field.
The information they provide for us that becomes approved SAMMI standard, is consistent in the listed data, as is the method for combining the components. You can try to justify trial and error all you like, but it's merely something you have invented that works for you in your gun, and hasn't caused you a problem while riding that fine line. It's certainly not a good practice to suggest to someone who doesn't know better to adopt a mentality that inspires them to ignor safe hand loading practices, and then to just go with their instincts after dangerous trial and error.
A standard is something that is determined to be effective in a wide range of normal applications, safely. Determined is a key word here that is established by expensive equipment that simulates it's intended application and is determined or proven to be safe.
Mixing powders, using primers for unintended application, seating bullets deeper than listed data are all clearly identified in reloading books as don't dos. The average hand loader doesn't possess the education and certification more importantly to determine that SAMMI specifications do not apply or are without merit.