To get the benefits of moly, you will need to start with a barrel completely devoid of copper fouling. Supposedly, it'll take about ten rounds for the moly to plate the inside of the barrel before the POI stabilizes.
Personally, I haven't seen that the POI shifts much in the first few rounds. I haven't seen much change in POI the few times I've been forced to mix moly and non-coated bullets, but then again, I was shooting at short range (300yds or less).