50-100 years ago it was common practice to torque threads to a fasteners yield strength to help prevent loosening in low vibration applications, with additional lock wire, lock washers, staking screws, etc for high vibration applications. Colt and Winchester used staking screws, for example. Do you have a torque wrench set up with a clamping mechanism for your cylinder ejector rod? If not, it’s pure guess work unless you’ve done it a bunch, like a gunsmith or pistol assembler has.
Use nail polish if you’re cheap, you want your wife to come to the rescue and your gun spends most of its time in the safe.
Threadlocker is used in all industries these days, for good reasons, and have come a long ways in the last 20 years. The new stuff wasn’t available to S&W armorers back in the day. I bet a bunch of revolvers out there these days have red Loctite because Walmart sells it, but it is a terrible choice as posted above.
For the cylinder rod, I suggested Loctite 222 or Permatex Purple with as tight as you can get the ejector rod with your fingers. The cylinder release button screw can get blue or purple threadlocker. I use blue because I can use a screwdriver for disassembly.
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