Hawk,Your 52HPBT is very well suited to the 1/12 barrel.
This difficultly in opening the bolt you discribed is it getting progressively more difficult to open?
Is the difficulty in raising the bolt or opening the chamber (pulling the empty from the chamber)? Im guess as you raise the handle.
If you try to rechamber the same empty does it remain the same level of difficulty when trying close AND then as you try to eject it the second time?
Does it occur when you drop down to say 24 gr of powder?
When you say it seems to occur when you reach 100 rounds does that mean after 100 rounds of continous firing or are the 100 rounds over 3 - 4 sessions?
Check your scales against a known standard, a 52 grain bullet is good, and be sure they are right on.
How many times have you loaded the brass.
After you shoot when you set the empty on a very flat surface does it rock like the primer has backed out a little?
Im really curious whats making this happen. If your shooting 100 rounds back to back and your not letting the barrel cool down you will experience the chamber contracting around the case as it returns to size after the round is fired. A very hot chamber does not remain the same size when using hot loads or loads near max. It is know that the chamber expands the case follows suit and immediately the chamber returns to size over the the swollen case making it difficult to extract. This is more common with very high pressure handgun loads fired in revolvers. .454, the .475 Limbaugh and the .500 SW. Some gun are very bad about this, Taurus and Ruger for sure. The entire cylinder expands trapping the cases and they can be very hard to get out. Keep in mind these are very hot loads. (but not with factory loads.....
Its probably not what your experiencing but it could under the right condition.
Just out of curiousity is it consistant or intermittant? When you shoot again and experience this difficulty shoot another round then wait 5 minutes before you aopen the bolt and see if it still is resistant.
Does it happen when you shoot factory stuff? Or just your loads?