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I finally exhausted the last of an eight pound keg of N110 I purchased years ago. N110 had been my go to powder for full power 357 and hot 45 Colt loads since I started using it over ten years ago, hence the bulk purchase. Now N110 is no longer available in bulk, is hard to find and is priced about $33 a pound. I'd love to continue using N110 but I want something I can buy in bulk and won't cost me an arm and a leg. N110 is worth more, but not that much more. So I am going to be auditioning new powders for full power 357 Magnum and Ruger-only 45 Colt, mainly behind 125gr, 158gr and 250gr XTPs. I've got H110/296, AA#9, AA4100, Enforcer and Lil' Gun on my short list. I first started loading 357 Magnum with H110 but had switched to N110 by the time I bought my chronograph. Same with AA#9, tried it but never really chronoed it or did a lot of work with it. I've heard that 4100 and Enforcer are the same powder, still waiting to hear from Western Powders if this is true. If they are it will cut down on some testing. I recently tried IMR 4227 in 357 and 45 Colt but so far am unimpressed. It looks like it could be promising in 45 Colt but max loads in 357 Magnum, while quite accurate, were also quite slow. I get the same velocities with less than half as much Universal and the Universal loads are quite accurate too. I've also used 2400 and Blue Dot in the past and didn't care for either. In back to back testing I found that Blue Dot gave higher velocities than 2400 and did it with less powder. Both were too dirty for my tastes and after hearing about Alliant pulling data for Blue Dot paired with 125gr bullets I don't care to try it again. The new Speer 357 data with 2400 and standard primers looks promising so I may look into it again. Alliant's 300-MP looks like it could be a good powder too but it is so new that data is sparse in 357 and non-existent in 45 Colt so I'm going to pass on it for now. Any others I'm leaving out? What have your experiences been with these cartridges? Remember I'm looking at powders for full power loads so if I read "Unique", "Herco", "AA#7", "W231/HP38", etc. I may lose my mind. I've already settled on Universal for mid-range loads, have worked up outstanding loads with it and bought it in bulk so please don't try to sell me on a mid-range powder. Thanks.