It all depends on what you'll be using this gun for.
Home defense/car gun/camp gun - I'd go with a medium or large frame, double action, 4-6" barrel, .357/.38 like a Ruger GP100. Very pleasant to practice/plink with .38, and .357 solids are serious medicine for all but the largest bears.
CCW/Pocket carry - S&W 642 or 442. Check out the 642 club thread. However, I would not recommend a snubnose airweight revolver as a first handgun. It takes a lot of practice to become comfortable with these, and a larger, heavier revolver is better for learning the basics.
Hiking/hunting/general woods gun - Ruger Redhawk or S&W 629 .44 magnum. You can also practice with .44 special, much like the .38/.357 combo.
Target practice/plinking - A single-action .22 would probably be the most fun to shoot on a regular basis, would provide a great platform for learning the basics, and can later be kept in a camping bag as a "survival tool" along side a hatchet, knife, matches, compass, etc.
There are many good firearms manufacturers out there, but for a solid, rugged revolver, stick with Ruger and Smith & Wesson. Both have got it right, but if I had to choose one over the other, I'd give the slightest edge to Ruger based on the all-out ruggedness of their frames. Good luck!