Some years back I had moved from the mid west and left all my reloading stuff sitting in a storage shed for a good 6 years. As most know, the weather goes from sub zero to extreme humid summer temps out there. This stuff was poorly packaged, especially the primers, and I have since used all of it up with no noticable effects.
As far as powders are concerned, if it smells acidic or has a rather nasty odor compared to powders you've recently bought, it might be breaking down. I had some Longshot I tossed a while back because it would burn my eyes when I opened the container. But on the flip side, I used some IMR4350 that was over 40 yrs. old and it was still GTG.
GS