the slow vs fast powder thing is fairly simple to understand when you take into account that all of the powder is burned up after just a few inches. A fast powder load uses less powder to prevent overpressure, and the smaller volume of powder actually results in less pressure when the bullet nears the muzzle, more pressure when the bullet first leaves the case. A slower powder allows more powder to be used, and can maintain a higher average pressure from throat to muzzle with a lower peak pressure resulting in less strain on the gun with a higher velocity. Just by chance if the 06 is a garand, 4895 is the best choice. Maximum velocity (most of the time) comes at a loss in accuracy, but the ability to shoot heavier bullets (higher BC/better penetration) at the same velocity is where slow powders and "magnum" chamberings shine. I like a 180gr btsp over 56gr Hodgdon H4350 for a nice accurate long range load. I have not loaded for a weatherby, but imagine 4831 and a 200gr bullet would shoot well.