There's the best answer you can get without providing us more information. And as Lee asked, what powder measure are you using? There's surely someone here with the same measure that would instruct you on how to change it around.Most of the powder measures can be reconfigured to drop either way. Depends on how the handle is installed and where the metering unit is located, front or back.
On mine, powder drops into the measuring tube on the up stroke and then powder drops into the case on the down stroke.
I should have made myself more clear. I have a uniflow and a redding 10x. I was just wanting opinions which setup most preferred and worked best.