Should be no problem at all as long as you use a press to remove the std. Lg. Rifle primers. Primers ignite from impact not pressure. Using a press you're pushing it out with pressure, just don't drop the handle, even then if one should happen to go off it not a catastrophic event, however it might scare you. A person would have to hover over the top of the press to get hit by anything that might cause harm and even then very unlikely, possibably some powder like fragments "might" be felt.
Back in the old days when I first started reloading using the Lee "Slap-O-Matic" once in a great while a primer would "POP". Nothing happened except to my nerves. hahaha
Remember a single primer is not a stick of dynamite.
Oh and yes they can be used again, done it hundreds of times.